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RiboX Secures FDA IND Clearance for World's First Circular RNA-Based In Vivo CAR-T Therapy
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Fusion42 · 27 August 2026 · Fusion42 review
RiboX has secured FDA Investigational New Drug (IND) clearance for RXIM002, the world's first circular RNA-based in vivo CAR-T therapy using targeted lipid nanoparticle delivery for autoimmune cytopenias, enabling Phase I clinical development in the United States.
This Wire brief sits within Fusion42's coverage of Biotech.
◆ ◆ The Wire takeaway
You must reconsider clinical development in RNA therapies after this FDA clearance shifts CAR-T delivery towards in vivo approaches. Manufacturing and patient access models will change, opening new paths in autoimmune treatment.
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1 source · 9 Aug 2026
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