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RiboX Secures FDA IND Clearance for World's First Circular RNA-Based In Vivo CAR-T Therapy

Published

9 August 2026

Topic

opportunities

◆ Sectors

Biotech

◆ Geography

United States

◆ Source

Read at biopharmaapac.com →

◆ Verified

Fusion42 · 27 August 2026 · Fusion42 review

RiboX has secured FDA Investigational New Drug (IND) clearance for RXIM002, the world's first circular RNA-based in vivo CAR-T therapy using targeted lipid nanoparticle delivery for autoimmune cytopenias, enabling Phase I clinical development in the United States.

This Wire brief sits within Fusion42's coverage of Biotech, and 2 sources have reported it.

◆ ◆ The Wire takeaway

You must reconsider clinical development in RNA therapies after this FDA clearance shifts CAR-T delivery towards in vivo approaches. Manufacturing and patient access models will change, opening new paths in autoimmune treatment.

◆ Coverage

2 sources · 9 Aug 2026

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◆ Topics

Biotechcircular-rnacar-t-therapyfda-indautoimmune-diseasesrna-therapeutics