Wire · operational-macro
CMS Finalizes the GLOBE Model: A Most-Favored-Nation Drug Payment Framework for ...
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Fusion42 · 5 October 2026 · Fusion42 review
CMS finalized the GLOBE Model, a mandatory Medicare Part B drug payment system implementing most-favored-nation pricing with expanded exemptions narrowing its scope to fewer manufacturers and drugs. The model, effective January 1, 2027, faces expected litigation and incentivizes participation in the GENEROUS Medicaid pricing program as a strategic exemption.
This Wire brief sits within Fusion42's coverage of Healthtech Infrastructure.
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Your Medicare Part B drug pricing strategy just got a forced reset. Check if your drugs fall inside GLOBE’s narrow scope or if entering Medicaid’s GENEROUS program can shield you from costly rebate obligations.
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1 source · 5 Oct 2026
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