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Dronabinol for PTSD Nightmares Is Promising, and the Dual Diagnosis Question Changes ...
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Fusion42 · 24 August 2026 · Fusion42 review
A recent randomized trial showed dronabinol, a synthetic THC, significantly reduced PTSD nightmares, suggesting a new treatment avenue beyond prazosin. However, the study did not address patients with comorbid substance use disorders (SUD), a large portion of the PTSD population, creating clinical and regulatory challenges for broad adoption.
This Wire brief sits within Fusion42's coverage of Mental Health.
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Prescribing dronabinol for PTSD nightmares confronts you with a major clinical blind spot: comorbid substance use disorder patients are excluded from trials but form half your patient base. Address this gap immediately or risk losing market access as guidelines and real-world needs diverge.
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1 source · 24 Aug 2026
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