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Wire · opportunities

Novartis, Bristol Myers halt autoimmune CAR-T trials due to adverse events

31 August 2026 · By · Wire by Fusion42

Published

31 August 2026

Topic

opportunities

◆ Sectors

Biotech

◆ Geography

United States

◆ Source

Read at fiercebiotech.com →

◆ Verified

Fusion42 · 31 August 2026 · Fusion42 review

Novartis and Bristol Myers Squibb have paused several CAR-T cell therapy trials in autoimmune diseases due to immune-related adverse events, prompting safety reviews of their rapid manufacturing platform therapies targeting CD19.

This Wire brief sits within Fusion42's coverage of Biotech.

◆ ◆ The Wire takeaway

You face a sudden pause in autoimmune CAR-T trials targeting CD19 due to safety concerns around rapid manufacturing. This forces a rethink on trial risk management and heightens scrutiny on new cell therapies in autoimmune diseases.

◆ Coverage

1 source · 31 Aug 2026

◆ Related on Wire

◆ Topics

Biotechcar-tautoimmuneclinical-trialssafety-eventsbioscienceregulatory-pause