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Ivonescimab Cuts Death Risk 27% vs Pembrolizumab in NSCLC Trial
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Fusion42 · 14 September 2026 · Fusion42 review
Ivonescimab demonstrated a 27% reduction in death risk compared to pembrolizumab in a Phase III trial for PD-L1-positive advanced non-small cell lung cancer, with a stronger effect in high PD-L1 expression patients and a safety profile that may expand treatment to squamous histology patients.
This Wire brief sits within Fusion42's coverage of Biotech.
◆ ◆ The Wire takeaway
Ivonescimab's survival benefit and safer profile in squamous NSCLC disrupt the current PD-L1 immunotherapy standard, creating a fresh clinical opportunity for biotech founders focused on lung cancer treatments.
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1 source · 14 Sep 2026
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