Wire · regulatory
Ractigen Therapeutics Announces U.S. FDA IND Clearance for First-in-Class saRNA ...
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Fusion42 · 31 July 2026 · Fusion42 review
Ractigen Therapeutics has received FDA clearance for an Investigational New Drug (IND) application to begin Phase I/IIa clinical trials for RAG-1C. The drug is a first-in-class small activating RNA (saRNA) therapeutic targeting Proliferative Vitreoretinopathy (PVR), a severe eye condition with no approved pharmacological treatments.
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◆ ◆ The Wire takeaway
The FDA has just de-risked the clinical path for small activating RNA. If you're building with an RNA modality beyond simple silencing or replacement, there is now a precedent for IND approval.
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