Starving Tumors on a Chip: Glucose and Oxygen Steer Cancer Growth

Researchers at the University of Zaragoza developed a microfluidic 3D model to study lung adenocarcinoma spheroids, showing how glucose, glutamine, and oxygen levels distinctly affect tumor growth, architecture, and stress signalling. The study reveals glutamine is essential for spheroid formation and growth, while glucose's effect varies with oxygen conditions, challenging assumptions about nutrient toxicity and metabolic adaptation in tumors.

This Wire brief sits within Fusion42's coverage of Biotech.